|
Symbol Name ID |
Notch2
notch 2 MGI:97364 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
increased B cell proliferation |
increased spleen weight |
abnormal B cell differentiation |
decreased transitional stage B cell number |
decreased transitional stage T2 B cell number |
increased transitional stage T1 B cell number |
arrested B cell differentiation |
decreased mature B cell number |
decreased B-1 B cell number |
decreased B-1a cell number |
decreased B-2 B cell number |
decreased follicular B cell number |
decreased marginal zone B cell number |
absent marginal zone B cells |
increased marginal zone B cell number |
decreased B cell number |
decreased pre-B cell number |
increased T cell number |
increased osteoclast cell number |
abnormal osteoclast morphology |
decreased spleen B cell follicle size |
decreased spleen germinal center number |
abnormal spleen marginal zone morphology |
decreased splenocyte number |
decreased IgG1 level |
decreased IgG3 level |
decreased IgM level |
abnormal marginal zone B cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal cytotoxic T cell physiology |
increased circulating interleukin-6 level |
abnormal interleukin level |
increased interleukin-6 secretion |
increased susceptibility to parasitic infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||
| Notch2Gt(betageo)1Byg/Notch2+ | |||||||||||||||||||||||||||||||||||||
| Notch2tm1.1Ecan/Notch2+ | |||||||||||||||||||||||||||||||||||||
| Notch2tm1.1Hhtg/Notch2+ | |||||||||||||||||||||||||||||||||||||
| Notch2tm1Yha/Notch2+ | |||||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn (conditional) |
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| Notch2tm1.1Hhi/Notch2tm1.1Hhi Tg(Cd8a-cre)1Itan/0 (conditional) |
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| Notch2tm1Frad/Notch2tm1Frad Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Notch2tm2.1Ecan/Notch2tm2.1Ecan Tg(BGLAP-cre)1Clem/0 (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Notch2tm2Hhi/Notch2tm1.1Hhi (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Notch2tm1.1Hhi/Notch2+ (conditional) |
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| Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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| Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+ Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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| Notch2tm2Hhi/Notch2tm1.1Hhi Tg(Mx1-cre)1Cgn/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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